SPOKANE, Wash. - UPDATE: The highway is back open.
Deputies say a pickup crossed the center line and hit an oncoming car head on.
The driver of that pickup, identified as Randy J. Peone, 49, later died at the hospital.
A third car was unable to avoid the collision and ran into those cars. The driver of both cars were also taken to Sacred Heart with serious injuries.
A three car crash is fully blocking Highway 291 five miles north of Spokane.
The crash happened at 3:24 p.m. Thursday.
There's no estimate for when the road will reopen.
Washington State Patrol is on scene.