Since her release from an Italian prison, Amanda Knox has been trying to stay out of the public eye back in her hometown, Seattle.
She returned to her studies at the University of Washington and kept her head down. According to family spokesman David Marriott, Knox is a junior studying creative writing and is currently on break after finishing the school's winter quarter.
Her first step back out of the shadows was to come this spring, with the publication of her account of the ordeal, titled "Waiting to be Heard."
But the decision of Italy's Supreme Court on Tuesday to quash her acquittal and order a retrial for the murder of former roommate Meredith Kercher has thrust her back into the spotlight.
Knox has come out fighting.
"No matter what happens, my family and I will face this continuing legal battle as we always have, confident in the truth and with our heads held high in the face of wrongful accusations and unreasonable adversity," she said in a statement.
The court's decision was "painful," but the prosecution should be held accountable for the "many discrepancies in their work," she said -- not just for her own and former boyfriend Raffaele Sollecito's sake, but also for the family of Meredith Kercher.
The semi-naked body of the 21-year-old British student, her throat slashed, was found in November 2007 at the home she shared with Knox in Perugia, Italy.
The case has gripped the attention of the public in the United States, Italy and Britain ever since.
Part of the fascination lies in the competing narratives spun around Knox, and the many questions raised about her true character.
Dream turns to nightmare
Her younger sister, Deanna Knox, painted a picture of a wanderlust-driven young American who had hit the books hard and worked multiple jobs since high school so she could study abroad.
The chance to study at the University for Foreigners of Perugia was a dream come true for Amanda, Deanna Knox said.
And she fell instantly in love with the charming four-bedroom villa overlooking a small valley into which she moved after spotting a small ad on first arriving in town with her sister.
"She didn't need to see any other place, she didn't need to see any other listings, she was set," said Deanna Knox.
Kercher, a British exchange student, moved into the house shortly after Amanda Knox settled in. The two foreigners became fast friends, Knox's friends and family say, as they explored Perugia together.
Just weeks later, the home would be the scene of a grisly stabbing that would leave Kercher dead and Knox branded as her cold-blooded killer.
Prosecutors in Perugia said Knox directed Sollecito and another man infatuated with her, Rudy Guede, to hold Kercher down as Knox played with a knife before slashing Kercher's throat.
Both Sollecito and Knox were convicted in 2009 and sentenced to lengthy jail terms. Guede, a drifter originally from the Ivory Coast, was tried separately and is serving a 16-year sentence.
Then, after the evidence was reexamined, an appeals court quashed the two students' convictions in October 2011, citing a lack of evidence against them, and both were set free to return to a "normal" life.
Fast-forward 17 months and, in a case with as many twists and turns as a thriller, both face the prospect of reliving the whole process again -- this time in a Florence appeals court.
Sollecito has already published his memoir, titled "Honor Bound: My Journey to Hell and Back with Amanda Knox."
In it, he writes that at times, he was uncomfortable with Knox's "bizarre behavior" after Kercher's death, which he says prosecutors used against both of them.
Knox's full version of events has not yet been heard.
But her own book will be "a full and unflinching account of the events that led to her arrest in Perugia and her struggles with the complexities of the Italian judicial system," according to publisher Harper Collins.